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Epidemiological reports advise a possible danger of spontaneous abortion and congenital abnormalities in infants whose mothers were being dealt with with one hundred fifty mg of fluconazole as one or recurring dose in the initial trimester, but these epidemiological research have limitations and these findings haven't been verified in managed clinical trials.
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Moreover, in a very randomized crossover examine with 12 healthy volunteers, it had been proven that fluconazole delayed the elimination of fentanyl noticeably. Elevated fentanyl concentration may produce respiratory depression.
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There have already been studies that an interaction exists when fluconazole is administered concomitantly with rifabutin, resulting in greater serum amounts of rifabutin as many as 80%.
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clients on long-phrase treatment with fluconazole and prednisone needs to be meticulously monitored for adrenal cortex insufficiency when fluconazole is discontinued.
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